Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.
Hirotaka IwakiCornelis BlauwendraatHampton L LeonardGanqiang LiuAstrid Elisabeth Mork-JanssonJean-Christophe CorvolLasse PihlstromMarlies van NimwegenSamantha J HuttenKhanh-Dung H NguyenJacqueline RickShirley EberlyFaraz FaghriPeggy AuingerKirsten M ScottRuwani WijeyekoonVivianna M Van DeerlinDena G HernandezAaron G Day-WilliamsAlexis BriceGuido Werner AlvesAlastair J NoyceOle-Bjørn TysnesJonathan R EvansDavid P BreenKarol EstradaClaire E WegelFabrice DanjouDavid K SimonBernard RavinaMathias ToftPeter HeutinkBastiaan R BloemDaniel WeintraubRoger A BarkerCaroline H Williams-GrayBart P van de WarrenburgJacobus J Van HiltenClemens R ScherzerAndrew B SingletonMike A NallsPublished in: Neurology. Genetics (2019)
This study provides evidence that alleles associated with Parkinson disease risk, in particular GBA variants, also contribute to the heterogeneity of multiple motor and nonmotor aspects. Accounting for genetic variability will be a useful factor in understanding disease course and in minimizing heterogeneity in clinical trials.