Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells.

Shingo ItoGentaro HondaYu FujinoSeiryo OgataMio Hirayama-KurogiSumio Ohtsuki

Published in: Pharmaceutical research (2019)

Our results suggest that suppression of SLC22A18 decreased the supply of intracellular free fatty acids from triglyceride-rich lipid droplets by impairing the lysosomal/autophagy degradation pathway and reduced the invasive activity of HepG2 cells by decreasing IGFBP-1 expression.

Keyphrases

fatty acid
poor prognosis
cell death
endoplasmic reticulum stress
signaling pathway
reactive oxygen species
binding protein