Rapid increase in immune surveillance and expression of NKT and γδT cell activation markers after consuming a nutraceutical supplement containing Aloe vera gel, extracts of Poria cocos and rosemary. A randomized placebo-controlled cross-over trial.
Liu YuSage V McGarryDina CruickshankGitte S JensenPublished in: PloS one (2023)
Consumption of APR extract triggered acute changes to chemokine levels. In addition, immune alertness was increased via the expression of activation markers on multiple types of innate immune cells, followed by increased immune surveillance and antioxidant protection. This suggests a beneficial enhancement of natural immune surveillance, likely via a combination of gut-mediated cytokine release and vagus nerve communication, in combination with cellular protection from oxidative stress.
Keyphrases
- oxidative stress
- public health
- poor prognosis
- immune response
- study protocol
- clinical trial
- phase ii
- phase iii
- placebo controlled
- randomized controlled trial
- liver failure
- binding protein
- radiation therapy
- squamous cell carcinoma
- intensive care unit
- induced apoptosis
- long non coding rna
- acute respiratory distress syndrome
- signaling pathway
- hyaluronic acid