Primary gastric diffuse large B-cell lymphoma: A multicentre retrospective study.
Cameron S LewisGreta JoyPaw JensenAllison BarracloughNunzio FrancoDipti TalaulikarEliza A HawkesTarec Christoffer El-GalalyDiego R VillaMichael J DickinsonJohn Francis SeymourChan Yoon Y CheahPublished in: British journal of haematology (2024)
Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) accounts for the majority of extra-nodal DLBCL. Even so, literature is lacking on early, localised presentations. We studied a cohort of patients with stage I disease, diagnosed between 2006 and 2018, from six centres between Australia, Canada and Denmark. Our goal was to characterise outcomes, review treatment and investigate the role of interim positron emission tomography (iPET). Thirty-seven eligible patients were identified. The median duration of follow-up was 42.2 months. All received chemoimmunotherapy with 91.9% (n = 34) given rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP). 35.1% (n = 13) underwent consolidative radiotherapy. Eighteen patients were H. pylori positive and 11 had the documentation of H. pylori eradication therapy. The 4-year progression-free survival and overall survival of R-CHOP was 88% (95% CI: 71-95) and 91% (95% CI: 75-97) respectively. All patients who achieved a partial metabolic response or complete metabolic response on iPET went on to achieve complete response at the end of treatment. R-CHOP-based therapy with iPET assessment appears to offer favourable outcomes, with radiotherapy and H. pylori eradication therapy implemented on a case-by-case basis.
Keyphrases
- diffuse large b cell lymphoma
- epstein barr virus
- end stage renal disease
- positron emission tomography
- free survival
- ejection fraction
- newly diagnosed
- chronic kidney disease
- early stage
- computed tomography
- peritoneal dialysis
- prognostic factors
- clinical trial
- randomized controlled trial
- radiation therapy
- drug delivery
- lymph node
- low dose
- squamous cell carcinoma
- helicobacter pylori infection
- high dose
- mesenchymal stem cells
- metabolic syndrome
- cross sectional
- study protocol
- radiation induced
- cancer therapy
- double blind
- pet imaging