Prevalence and mortality associations of interstitial lung abnormalities in rheumatoid arthritis within a multicentre prospective cohort of smokers.
Gregory C McDermottKeigo HayashiKazuki YoshidaMatthew MollMichael H ChoTracy J DoyleGregory L KinneyPaul F DellaripaRachel K PutmanRaul San Jose EsteparAkinori HataTakuya HinoTomoyuki HidaMasahiro YanagawaMizuki NishinoGeorge WashkoElizabeth A ReganHiroto HatabuGary M HunninghakeEdwin K SilvermanJeffrey A SparksPublished in: Rheumatology (Oxford, England) (2023)
In this cohort of smokers, RA was associated with ILAs and this persisted after adjustment for current/past smoking and genetic/lifestyle risk factors. RA with ILAs in smokers had a 3-fold increased all-cause mortality, emphasizing the importance of further screening and treatment strategies for preclinical ILD in RA.
Keyphrases
- rheumatoid arthritis
- smoking cessation
- risk factors
- interstitial lung disease
- disease activity
- ankylosing spondylitis
- systemic sclerosis
- cardiovascular disease
- metabolic syndrome
- physical activity
- clinical trial
- genome wide
- cardiovascular events
- randomized controlled trial
- study protocol
- stem cells
- copy number
- cross sectional
- dna methylation
- idiopathic pulmonary fibrosis
- gene expression
- mesenchymal stem cells
- bone marrow
- cell therapy
- double blind