Cotrimoxazole prophylaxis was associated with enteric commensal bacterial resistance among HIV-exposed infants in a randomized controlled trial, Botswana.
Kathleen M PowisSajini SoudaShahin LockmanGbolahan AjibolaKara BennettJean LeidnerMichael D HughesSikhulile MoyoErik van WidenfeltHaruna B JibrilJoseph MakhemaMax EssexRoger L ShapiroPublished in: Journal of the International AIDS Society (2018)
HIV-exposed infants randomized to CTX prophylaxis had increased CTX-resistant commensal gastrointestinal bacteria compared with placebo recipients. Additional research is needed to determine the longer-term clinical, microbiologic, and public health consequences of antimicrobial resistance selected by infant CTX prophylaxis.
Keyphrases
- antimicrobial resistance
- antiretroviral therapy
- public health
- hiv positive
- hiv infected
- hiv testing
- klebsiella pneumoniae
- human immunodeficiency virus
- double blind
- hepatitis c virus
- hiv aids
- men who have sex with men
- phase iii
- placebo controlled
- open label
- preterm infants
- randomized controlled trial
- phase ii
- escherichia coli
- kidney transplantation
- global health