Early herpes and TTV DNAemia in septic shock patients: a pilot study.
François MalletMagali PerretTrang TranBoris MeunierAudrey GuichardOlivier TaboneMarine MommertKaren Brengel-PesceFabienne VenetAlexandre PachotGuillaume MonneretFrederic ReynierChristophe VédrinePhilippe LeissnerVirginie MoucadelAlain LepapeJulien Textorisnull nullnull nullPublished in: Intensive care medicine experimental (2019)
Applying a semi-automated process of viral DNAemia determination to this cohort of 98 patients with septic shock, we observed that the number of patients with positive viremia increased during the first week in the ICU. Of note, there was no improvement in predicting the outcome when using viremia status. Nevertheless, this pilot study, introducing standardized procedures from extraction to detection, provides the basis for future standardized diagnostic criteria. A prospective longitudinal clinical study using these procedures will enable determination of whether such viremia is due to a lack of a latent virus control by the immune system or a true clinical viral infection.
Keyphrases
- septic shock
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- machine learning
- prognostic factors
- sars cov
- deep learning
- molecularly imprinted
- clinical trial
- randomized controlled trial
- cross sectional
- current status
- high resolution
- loop mediated isothermal amplification
- sensitive detection