RAMP and MRAP Accessory Proteins have Selective Effects on Expression and Signalling of the CB1, CB2, GPR18 and GPR55 Cannabinoid Receptors.
Nathaniel A K GlennDavid B FinlayEmma R CarruthersKathleen G MountjoyChristopher S WalkerNatasha L GrimseyPublished in: British journal of pharmacology (2023)
Mutual influences on expression and/or function for specific accessory protein-receptor pairings raises the strong potential for physiological and disease-relevant consequences. CBR sequestration of and/or hetero-oligomerisation with accessory proteins is a possible novel mechanism for receptor crosstalk.