Pivotal functions and impact of long con-coding RNAs on cellular processes and genome integrity.
Siddhant SharmaAicha Asma HoufaniLeonard J FosterPublished in: Journal of biomedical science (2024)
Recent advances in uncovering the mysteries of the human genome suggest that long non-coding RNAs (lncRNAs) are important regulatory components. Although lncRNAs are known to affect gene transcription, their mechanisms and biological implications are still unclear. Experimental research has shown that lncRNA synthesis, subcellular localization, and interactions with macromolecules like DNA, other RNAs, or proteins can all have an impact on gene expression in various biological processes. In this review, we highlight and discuss the major mechanisms through which lncRNAs function as master regulators of the human genome. Specifically, the objective of our review is to examine how lncRNAs regulate different processes like cell division, cell cycle, and immune responses, and unravel their roles in maintaining genomic architecture and integrity.
Keyphrases
- poor prognosis
- long non coding rna
- cell cycle
- genome wide identification
- gene expression
- endothelial cells
- transcription factor
- genome wide
- genome wide analysis
- network analysis
- immune response
- cell proliferation
- copy number
- dna methylation
- pluripotent stem cells
- single cell
- single molecule
- circulating tumor
- dendritic cells
- toll like receptor
- bone marrow