Differential 5-year brain atrophy rates in cognitively declining and stable APOE-ε4 elders.

Dana A KellyMichael SeidenbergKatherine ReiterKristy A Nielson John L WoodardJ Carson SmithSally DurgerianStephen M Rao

Published in: Neuropsychology (2018)

This study illustrates the variability in phenotypic expression of the ε4 allele related to neurodegeneration. Specifically, only those individuals who exhibited longitudinal declines in cognitive function experienced concomitant changes in brain volume. Future research is needed to better understand the biological and lifestyle factors that may influence the expression of the ε4 allele. (PsycINFO Database Record

Keyphrases

poor prognosis
resting state
cognitive decline
white matter
functional connectivity
binding protein
physical activity
weight loss
cross sectional
high fat diet
cerebral ischemia
mild cognitive impairment
type diabetes
emergency department
multiple sclerosis
brain injury
electronic health record