Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cells.
Rogan A GrantLuisa Morales-NebredaNikolay S MarkovSuchitra SwaminathanEstefany R GuzmanDarryl A AbbottHelen K DonnellyAlvaro DonayreIsaac A GoldbergZasu M KlugNicole BorkowskiZiyan LuHermon KihshenYuliya PolitanskaLango SichizyaMengjia KangAli ShilatifardChao QiA Christine ArgentoJacqueline M KruserElizabeth S MalsinChiagozie O PickensSean B SmithJames M WalterAnna E PawlowskiDaniel SchneiderPrasanth NannapaneniHiam Abdala-ValenciaAnkit BharatCara J GottardiG R Scott BudingerAlexander V MisharinBenjamin David SingerRichard G Wunderinknull nullPublished in: bioRxiv : the preprint server for biology (2020)
SARS-CoV-2-infected alveolar macrophages form positive feedback loops with T cells in patients with severe COVID-19.