Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations.
Mohammed AboukaoudShoshana IsraelChaim BrautbarSara EyalPublished in: Pharmaceutical research (2018)
Genetic variation can affect drug pharmacokinetics and pharmacodynamics and contribute to variability between individuals in response to medications. Specifically, differences in allele frequencies among individuals and ethnic groups have been associated with variation in their propensity to develop drug hypersensitivity reactions (HSRs). This article reviews the current knowledge on the genetic background of HSRs and its relevance to Jewish and Arab populations. The focus is on human leukocyte antigen (HLA) alleles and haplotypes as predictive markers of HSRs ("immunopharmacogenetics"), but other genes and alleles are described as well. Also discussed is the translation of the pharmacogenetic information to practice recommendations.
Keyphrases
- drug induced
- genome wide
- healthcare
- endothelial cells
- primary care
- copy number
- dna methylation
- adverse drug
- induced pluripotent stem cells
- genetic diversity
- pluripotent stem cells
- emergency department
- clinical practice
- systematic review
- randomized controlled trial
- quality improvement
- social media
- electronic health record
- genome wide identification