Alcohol Abstainer Status and Prazosin Treatment in Association with Changes in Posttraumatic Stress Disorder Symptoms in Veterans with Comorbid Alcohol Use Disorder and Posttraumatic Stress Disorder.

Terril L VerplaetseElizabeth RalevskiWalter RobertsRalitza GueorguievaSherry A McKeeIsmene L Petrakis

Published in: Alcoholism, clinical and experimental research (2019)

Overall, prazosin treatment was not significantly related to changes in PTSD symptoms over the course of the 12-week clinical trial in a comorbid population. Interestingly, placebo-treated alcohol nonabstainers had a significant reduction in PTSD symptoms. Whether placebo-treated individuals continued to use alcohol because of ongoing symptoms of PTSD is not known.

Keyphrases

posttraumatic stress disorder
clinical trial
sleep quality
alcohol use disorder
alcohol consumption
randomized controlled trial
social support
physical activity
combination therapy
study protocol
newly diagnosed
phase ii
drug induced