Nanosilver particles increase follicular atresia: Correlation with oxidative stress and aromatization.
Masumeh MirzaeiMazdak RaziRajabali SadrkhanlouPublished in: Environmental toxicology (2017)
Present study was performed in order to update the possible mechanism(s), involving in nanosilver particles (NSPs)-induced detrimental impacts in ovarian tissue. For this purpose, 24 mature female rats were divided into control and 0.5, 1, 5 mg/kg NSPs-received groups (intraperitoneally, for 35 days). Follicular growth and atresia, ovarian total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) contents, serum estrogen (E2 ) level and macrophages infiltration were investigated. Moreover, ovarian angiogenesis, cellular mRNA damage and cytochrome aromatase CYP19 expression were analyzed. The NSPs enhanced follicular atresia diminished E2, reduced TAC and SOD level, elevated MDA content and up-regulated macrophages infiltration. Cellular mRNA damage, impaired angiogenesis and diminished CYP19 expression were revealed in NSPs-received groups. Therefore NSPs by down-regulating aromatization, reduce E2 synthesis which then it leads to impaired angiogenesis. The impaired angiogenesis in turn down-regulates ovarian antioxidant status, which partially enhances follicular atresia by triggering lipid peroxidation and mRNA damage.
Keyphrases
- oxidative stress
- endothelial cells
- vascular endothelial growth factor
- diabetic rats
- binding protein
- poor prognosis
- high glucose
- wound healing
- breast cancer cells
- ischemia reperfusion injury
- dna damage
- amyotrophic lateral sclerosis
- transcription factor
- induced apoptosis
- long non coding rna
- drug induced
- living cells
- fatty acid
- estrogen receptor
- heat stress
- cell cycle arrest
- high speed
- pi k akt