Combined VEGF/PDGF inhibition using axitinib induces αSMA expression and a pro-fibrotic phenotype in human pericytes.

Jakob SiedleckiBen AsaniChristian WertheimerAnna HillenmayerAndreas OhlmannClaudia PriglingerSiegfried PriglingerArmin WolfKirsten Eibl-Lindner

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2018)

Combined anti-VEGF/PDGF inhibition seems to induce a proto-myofibroblast-like phenotype in human pericytes in vitro, but reduce profibrotic cellular mechanisms due to prolonged anti-PDGF inhibition.

Keyphrases

endothelial cells
smooth muscle
vascular endothelial growth factor
vascular smooth muscle cells
induced pluripotent stem cells
poor prognosis
pluripotent stem cells
long non coding rna
signaling pathway