CIDP: Analysis of Immunomarkers During COVID-19 mRNA-Vaccination and IVIg-Immunomodulation: An Exploratory Study.
Martin K R SvačinaAnika MeißnerFinja SchweitzerAlina Sprenger-SvačinaInes KleinHauke WüstenbergFelix KohleHelene L WalterMichael SchroeterHelmar C LehmannPublished in: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2023)
Availability of COVID-19 mRNA vaccine for patients with chronic inflammatory demyelinating polyneuropathy (CIDP) treated with intravenous immunoglobulin (IVIg) raises the question of whether COVID-19 mRNA vaccine influences disease activity or IVIg-mediated immunomodulation in CIDP. In this exploratory study, blood samples of CIDP patients on IVIg treatment were longitudinally analyzed before and after vaccination with a COVID-19 mRNA vaccine. A total of 44 samples of eleven patients were characterized at four timepoints by ELISA and flow cytometry in terms of immunomarkers for disease activity and IVIg-immunomodulation. Apart from a significantly lower expression of CD32b on naïve B cells after vaccination, no significant alteration of immunomarkers for CIDP or IVIg-mediated immunomodulation was observed. Our exploratory study suggests that COVID-19 mRNA vaccine does not have a relevant impact on immune activity in CIDP. In addition, immunomodulatory effects of IVIg in CIDP are not altered by COVID-19 mRNA vaccine. This study was registered in the German clinical trial register (DRKS00025759). Overview over the study design. Blood samples of CIDP patients on recurrent IVIg treatment and vaccination with a COVID-19 mRNA vaccine were obtained at four timepoints for cytokine ELISA and flow cytometry, to assess key cytokines and cellular immunomarkers for disease activity and IVIg-immunomodulation in CIDP.
Keyphrases
- disease activity
- coronavirus disease
- sars cov
- rheumatoid arthritis
- systemic lupus erythematosus
- end stage renal disease
- flow cytometry
- rheumatoid arthritis patients
- newly diagnosed
- clinical trial
- ejection fraction
- ankylosing spondylitis
- chronic kidney disease
- juvenile idiopathic arthritis
- peritoneal dialysis
- binding protein
- prognostic factors
- poor prognosis
- high dose
- study protocol
- respiratory syndrome coronavirus