Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru.
Louis GrandjeanRobert H GilmanTomatada IwamotoClaudio Umberto KöserJorge CoronelMirko ZimicMichelle S TolemanDiepreye AyabinaMichelle KendallChristophe FraserSimon R HarrisJulian ParkhillSharon J PeacockDavid A J MooreCaroline ColijnPublished in: PloS one (2017)
Variation in these genes have a biologically plausible effect on immunogenicity and virulence. This makes functional characterization warranted to determine the effects of these polymorphisms on bacterial fitness and transmission.
Keyphrases
- multidrug resistant
- escherichia coli
- pseudomonas aeruginosa
- mycobacterium tuberculosis
- staphylococcus aureus
- physical activity
- gram negative
- body composition
- genome wide
- acinetobacter baumannii
- antimicrobial resistance
- biofilm formation
- hiv aids
- pulmonary tuberculosis
- klebsiella pneumoniae
- gene expression
- emergency department
- genome wide identification
- cystic fibrosis
- drug induced