Safety of intravitreally delivered AAV2 vector-mediated multi-characteristic opsin genetic construct in wild type beagle dogs.
Samarendra MohantySubrata BatabyalAnanta AyyagariNajam A Sharif
Published in: The journal of gene medicine (2024)
gc per eye, with no adverse effects observed. This dose was identified as the No Observed Adverse Effect Level (i.e. NOAEL) and guided selection of safe doses for human clinical trials.