Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia.
Mark S WilliamsTim C P SomervaillePublished in: Molecular & cellular oncology (2020)
The drug efflux pump ABCB1 (ATP binding cassette subfamily B member 1) confers chemotherapy resistance in acute myeloid leukemia (AML). We recently identified an ABCB1 enhancer that is activated in response to a range of cellular stressors, including anthracycline chemotherapy. Stress drives increased ABCB1 expression and allows leukemia cells to escape from targeted third-generation ABCB1 inhibition.
Keyphrases
- binding protein
- acute myeloid leukemia
- induced apoptosis
- cancer therapy
- locally advanced
- transcription factor
- poor prognosis
- cell cycle arrest
- bone marrow
- stress induced
- squamous cell carcinoma
- radiation therapy
- cell death
- allogeneic hematopoietic stem cell transplantation
- drug delivery
- acute lymphoblastic leukemia
- oxidative stress