Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia.
Sonja SchöneckerFrancisco Jesús Martinez-MurciaJannis DeneckeNicolai FranzmeierAdrian DanekOlivia WagemannCatharina PrixElisabeth WlasichJonathan VögleinSandra V LoosliAnna BrauerJuan-Manuel Górriz SáezArabella BouziguesLucy L RussellPhoebe H FosterEve Ferry-BolderJohn C van SwietenLize C JiskootHarro SeelaarRaquel Sanchez-ValleRobert Jr LaforceCaroline GraffDaniela GalimbertiRik VandenbergheAlexandre de MendonçaPietro TiraboschiIsabel SantanaAlexander GerhardSandro SorbiMarkus OttoFlorence PasquierSimon DucharmeChristopher ButlerIsabelle Le BerElizabeth FingerMaria Carmela TartagliaMario MasellisJames Benedict RoweMatthis SynofzikFermin MorenoBarbara BorroniJonathan D Rohrernull nullJosef PrillerGünter U HöglingerJohannes LevinPublished in: Neurology (2024)
We identified multiple clusters of behavioral and neuropsychiatric symptoms in participants with genetic FTD that relate to distinct cerebral atrophy patterns. Their severity depends on time, affected gene, sex, and education. These clinical-genetic associations can guide diagnostic evaluations and the design of clinical trials for new disease-modifying and preventive treatments.