Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma.
Ana CostaCécile ThirantAmira KramdiCécile Pierre-EugèneCaroline Louis-BrennetotOrphée BlanchardDidier SurdezNadege GruelEve LapoubleGaëlle PierronDeborah SitbonHervé BrisseArnaud GauthierPaul FréneauxMylène BohecVirginie RaynalSylvain BaulandeRenaud LeclereGabriel ChampenoisAndre NicolasDidier MeseureAngela BelliniAurélien MarabelleBirgit GeoergerFatima Mechta-GrigoriouGudrun SchleiermacherLaurie MengerOlivier DelattreIsabelle Janoueix-LeroseyPublished in: Journal for immunotherapy of cancer (2022)
Our study demonstrates that neuroblastoma tumors have an immunocompromised microenvironment characterized by dysfunctional T cells and accumulation of immunosuppressive cells. Our work provides a new and precious data resource to better understand the neuroblastoma ecosystem and suggest novel therapeutic strategies, targeting both tumor cells and components of the microenvironment.
Keyphrases
- single cell
- stem cells
- induced apoptosis
- rna seq
- endothelial cells
- cell cycle arrest
- high throughput
- climate change
- cancer therapy
- machine learning
- cell death
- cell proliferation
- intensive care unit
- pluripotent stem cells
- human health
- acute respiratory distress syndrome
- respiratory failure
- pi k akt
- data analysis
- extracorporeal membrane oxygenation
- deep learning