Comparison of Clinical Characteristics and Outcomes of Younger and Elderly Patients with Severe COVID-19 in Korea: A Retrospective Multicenter Study.
Gil Myeong SeongAe Rin BaekMoon Seong BaekWon Young KimJin Hyoung KimBo Young LeeYong Sub NaSong I LeePublished in: Journal of personalized medicine (2021)
Old age is associated with disease severity and poor prognosis among coronavirus disease 2019 (COVID-19) cases; however, characteristics of elderly patients with severe COVID-19 are limited. We aimed to assess the clinical characteristics and outcomes of patients hospitalized with severe COVID-19 at tertiary care centers in South Korea. This retrospective multicenter study included patients with severe COVID-19 who were admitted at seven hospitals in South Korea from 2 February 2020 to 28 February 2021. The Cox regression analyses were performed to assess factors associated with the in-hospital mortality. Of 488 patients with severe COVID-19, 318 (65.2%) were elderly (≥65 years). The older patient group had more underlying diseases and a higher severity score than the younger patient group. The older patient group had a higher in-hospital mortality rate than the younger patient group (25.5% versus 4.7%, p -value < 0.001). The in-hospital mortality risk factors among patients with severe COVID-19 included age, acute physiology and chronic health evaluation II score, presence of diabetes and chronic obstructive lung disease, high white blood cell count, low neutrophil-lymphocyte ratio and platelet count, do-not-resuscitate order, and treatment with invasive mechanical ventilation. In addition to old age, disease severity and examination results must be considered in treatment decision-making.
Keyphrases
- coronavirus disease
- sars cov
- poor prognosis
- early onset
- respiratory syndrome coronavirus
- drug induced
- mechanical ventilation
- case report
- healthcare
- risk factors
- type diabetes
- tertiary care
- end stage renal disease
- intensive care unit
- long non coding rna
- public health
- community dwelling
- mental health
- peripheral blood
- peritoneal dialysis
- newly diagnosed
- liver failure
- metabolic syndrome
- cross sectional
- prognostic factors
- ejection fraction
- social media
- hepatitis b virus
- health information
- bone marrow
- extracorporeal membrane oxygenation
- replacement therapy