Multipanel Approach including miRNAs, Inflammatory Markers, and Depressive Symptoms for Metabolic Dysfunction-Associated Steatotic Liver Disease Diagnosis during 2-Year Nutritional Intervention.
Ana Luz Tobaruela-ResolaJosé-Ignacio Riezu-BojFermin Ignacio MilagroPaola Mogna-PelaezJose Ignacio HerreroMariana ElorzAlberto BenitoJosep Antonio TurJ Alfredo MartínezJosé Alfredo MartínezMaría de Los Ángeles ZuletPublished in: Nutrients (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD), with a prevalence of 30% of adults globally, is considered a multifactorial disease. There is a lack of effective non-invasive methods for accurate diagnosis and monitoring. Therefore, this study aimed to explore associations between changes in circulating miRNA levels, inflammatory markers, and depressive symptoms with hepatic variables in MASLD subjects and their combined potential to predict the disease after following a dietary intervention. Biochemical markers, body composition, circulating miRNAs and hepatic and psychological status of 55 subjects with MASLD with obesity and overweight from the FLiO study were evaluated by undergoing a 6-, 12- and 24-month nutritional intervention. The highest accuracy values of combined panels to predict the disease were identified after 24 months. A combination panel that included changes in liver stiffness, high-density lipoprotein cholesterol (HDL-c), body mass index (BMI), depressive symptoms, and triglycerides (TG) yielded an AUC of 0.90. Another panel that included changes in hepatic fat content, total cholesterol (TC), miR15b-3p, TG, and depressive symptoms revealed an AUC of 0.89. These findings identify non-invasive biomarker panels including circulating miRNAs, inflammatory markers, depressive symptoms and other metabolic variables for predicting MASLD presence and emphasize the importance of precision nutrition in MASLD management and the sustained adherence to healthy lifestyle patterns.
Keyphrases
- depressive symptoms
- body composition
- body mass index
- social support
- randomized controlled trial
- sleep quality
- weight gain
- physical activity
- weight loss
- metabolic syndrome
- oxidative stress
- cardiovascular disease
- adipose tissue
- bone mineral density
- risk factors
- resistance training
- risk assessment
- type diabetes
- single cell
- climate change
- high intensity
- low density lipoprotein