A Novel Approach to Link Genetics and Human MRI Identifies AKAP7-Dependent Subicular/Prefrontal Functional Connectivity as Altered in Suicidality.
Guillermo PobleteTien NguyenSavannah GosnellOlutayo SofelaMichelle PatriquinSanjay J MathewAlan SwannDavid A NielsenThomas R KostenRamiro SalasPublished in: Chronic stress (Thousand Oaks, Calif.) (2022)
PGL uncovered a brain function/genotype interaction in ATT by using published GWAS data to inform imaging studies. This could inform individualized therapies in the future.
Keyphrases
- functional connectivity
- resting state
- endothelial cells
- high resolution
- magnetic resonance imaging
- contrast enhanced
- electronic health record
- induced pluripotent stem cells
- genome wide
- pluripotent stem cells
- computed tomography
- randomized controlled trial
- case control
- diffusion weighted imaging
- multiple sclerosis
- dna methylation
- working memory
- blood brain barrier
- brain injury
- cerebral ischemia