The effects of atorvastatin on emotional processing, reward learning, verbal memory and inflammation in healthy volunteers: An experimental medicine study.
Riccardo De GiorgiMarieke Annie Gerdine MartensNicola Rizzo PesciPhilip J CowenCatherine J HarmerPublished in: Journal of psychopharmacology (Oxford, England) (2022)
Our results reveal for the first time the early influence of atorvastatin on emotional cognition by increasing the processing of anxiety-related stimuli (i.e. increased recognition, discriminability and misclassifications of fearful facial expression) in healthy volunteers, in the absence of more general effects on negative affective bias. Further studies exploring the effects of statins in depressed patients, especially with raised inflammatory markers, may clarify this finding and inform future clinical trials.
Keyphrases
- clinical trial
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- working memory
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- oxidative stress
- cardiovascular disease
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- prognostic factors
- randomized controlled trial
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- genome wide
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- patient reported outcomes
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