Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients.

Chaoyang SunYuzhe SunPing WuWencheng DingShiyou WangJiafeng LiLangchao LiangChaochao ChaiYu FuZhiming LiLinnan ZhuJia JuXin LiaoXiaoyuan HuangLing FengDing MaLiang HeDongsheng ChenGang ChenXin JinPeng Wu

Published in: Intensive care medicine experimental (2021)

Frequent transcriptional phase transitions may contribute to outcome in critically ill COVID-19 patients. Furthermore, fluctuation in red blood cell and hemoglobin levels may relate to poor prognosis. The biological function of melatonin was suppressed in COVID-19 non-survivors, which may provide a potential theoretical basis for clinical administration.

Keyphrases

red blood cell
poor prognosis
sars cov
long non coding rna
coronavirus disease
respiratory syndrome coronavirus
young adults
gene expression
transcription factor
single cell
cross sectional
human health
heat shock
oxidative stress
risk assessment