A rare codon-based translational program of cell proliferation.

Joao C GuimaraesNitish MittalAlexandra GnannDominik JedlinskiAndrea RibaKatarzyna BuczakAlexander SchmidtMihaela Zavolan

Published in: Genome biology (2020)

We propose that the alleviation of translation bottlenecks in rapidly dividing cells enables preferential upregulation of pro-proliferation proteins, encoded by mRNAs that are enriched in rare codons.

Keyphrases

cell proliferation
induced apoptosis
signaling pathway
cell cycle arrest
pi k akt
cell cycle
quality improvement
poor prognosis
anti inflammatory