Marmosets as model systems for the study of Alzheimer's disease and related dementias: substantiation of physiological Tau 3R and 4R isoform expression and phosphorylation.
Hasi HuheSarah M ShapleyDuc DuongFang WuSeung-Kwon HaSang-Ho ChoiJulia KoflerYongshan MouThais Rafael GuimaraesAmantha ThathiahLauren K H SchaefferGregory W CarterNicholas T SeyfriedAfonso C SilvaStacey J Sukoff RizzoPublished in: bioRxiv : the preprint server for biology (2024)
Our results confirm the expression of both 3R and 4R Tau isoforms and important phosphorylation residues in the marmoset brain. These data emphasize the significance of marmosets with natural expression of AD-related hallmarks as important translational models for the study of AD.