Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study.
Carla Perpiñá-ClériguesSusana MelladoJosé F Català-SenentFrancesc IbáñezPilar CostaMiguel MarcosConsuelo GuerriFrancisco García-GarcíaConsuelo GuerriPublished in: Biology of sex differences (2023)
Our results suggest that binge ethanol drinking in human female adolescents leads to a higher content of plasma EV lipid species associated with EV biogenesis and the propagation of neuroinflammatory responses than in males. In addition, we discovered greater differences in lipid abundance between sexes in WT mice compared to TLR4-KO mice. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
Keyphrases
- young adults
- physical activity
- high fat diet induced
- endothelial cells
- fatty acid
- inflammatory response
- high glucose
- lipopolysaccharide induced
- toll like receptor
- depressive symptoms
- lps induced
- traumatic brain injury
- type diabetes
- risk assessment
- wild type
- diabetic rats
- pluripotent stem cells
- insulin resistance
- single cell
- adipose tissue
- brain injury
- drug induced
- metabolic syndrome
- nuclear factor
- human health
- skeletal muscle
- microbial community
- climate change