Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN.
Guangjie LiuPeng HaoJie XuLiming WangYuchuan WangRuifang HanMing YingShuangshuang SuiJinghua LiuXuan LiPublished in: Respiratory research (2018)
Our data indicate that miR-17-5p might play a significant role in hypoxia-induced pulmonary vascular smooth muscle cell proliferation by regulating multiple gene targets, including PTEN and p21, and that miR-17-5p could be a novel therapeutic target for the management of hypoxia-induced PH.
Keyphrases
- cell proliferation
- pulmonary artery
- smooth muscle
- pulmonary hypertension
- pi k akt
- coronary artery
- pulmonary arterial hypertension
- signaling pathway
- cell cycle
- endothelial cells
- electronic health record
- induced pluripotent stem cells
- big data
- pluripotent stem cells
- copy number
- genome wide
- poor prognosis
- artificial intelligence
- transcription factor
- long non coding rna
- dna methylation
- genome wide analysis
- data analysis