Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy.
Daniel W SirkisCaroline Warly SolsbergTaylor P JohnsonLuke W BonhamVirginia E SturmSuzee E LeeKatherine P RankinHoward J RosenAdam L BoxerWilliam W SeeleyBruce L MillerEthan G GeierJennifer S YokoyamaPublished in: Genome medicine (2023)
Our results suggest that human peripheral immune cell expression and abundance are modulated by tau-associated pathophysiologic changes. CX3CR1 and nonclassical monocytes in particular will be a focus of future work exploring the role of these peripheral signals in additional tau-associated neurodegenerative diseases.