Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC.

Sagar D Sardesai Alexandra Thomas Christopher M GallagherFilipa LynceYvonne Lynn OttavianoTarah Jean BallingerBryan P SchneiderAnna Maria StornioloAmber BauchleSandra K AlthouseSusan M PerkinsAndrea R Masters Robert E StratfordZizheng DongJing-Yuan LiuJian-Ting ZhangKathy D Miller

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

FASN is commonly expressed in early TNBC. Omeprazole can be safely administered in doses that inhibit FASN. The addition of omeprazole to neoadjuvant AC-T yields a promising pCR rate that needs further confirmation in randomized studies.

Keyphrases

neoadjuvant chemotherapy
locally advanced
lymph node
rectal cancer
fatty acid
sentinel lymph node
squamous cell carcinoma
double blind
open label
signaling pathway
placebo controlled
phase iii
phase ii
randomized controlled trial