Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes.
Christian K DyeMichael J CorleyClaire IngAnnette Lum-JonesDongmei LiMarjorie K L M MauAlika K MaunakeaPublished in: Clinical epigenetics (2022)
Our pilot study provides preliminary evidence of changes to inflammatory monocyte activity, potentially driven by epigenetic modifications, 3 months following a DM-specific SSP intervention. These novel alterations in the trajectory of monocyte inflammatory states were identified at loci that regulate transcription of immune and metabolic genes in high-risk Native Hawaiians with DM, suggesting a relationship between improvements in psychosocial behaviors and shifts in the immunoepigenetic patterns following a diabetes-specific SSP. Further research is warranted to investigate how social support influences systemic inflammation via immunoepigenetic modifications in chronic inflammatory diseases such as DM.
Keyphrases
- social support
- glycemic control
- depressive symptoms
- type diabetes
- cardiovascular disease
- dendritic cells
- randomized controlled trial
- oxidative stress
- genome wide
- peripheral blood
- dna methylation
- endothelial cells
- mental health
- adipose tissue
- transcription factor
- insulin resistance
- weight loss
- single cell
- skeletal muscle