Effect of dapagliflozin on cardiac function and metabolic and hormonal responses to exercise.
Roselle A HerringIain T ParsonsFariba Shojaee-MoradieMary StevenageNicola JacksonRalph J F MandersA Margot UmplebyBarbara A FieldingMelanie DaviesDavid L Russell-JonesPublished in: The Journal of clinical endocrinology and metabolism (2022)
During exercise GH may be more important than catecholamines in driving the shift from glucose to fatty acid metabolism by SGLT2 inhibitors. The 4-week crossover design showed changes in cardiac function were rapid in onset and reversible.