Comprehensive evaluation of the metabolic effects of porcine CRTC3 overexpression on subcutaneous adipocytes with metabolomic and transcriptomic analyses.

Jiaqi LiuJie LiWentao ChenXintao XieXingang ChuTeresa G ValencakYizhen WangTizhong Shan

Published in: Journal of animal science and biotechnology (2021)

We identified significant alterations in the metabolite composition and the expression of genes and pathways involved in lipid metabolism in CRTC3-overexpressing adipocytes. Our results suggest that CRTC3 might play an important regulatory role in lipid metabolism and thus affects lipid accumulation in porcine subcutaneous adipocytes.

Keyphrases

adipose tissue
transcription factor
poor prognosis
high fat diet induced
cell proliferation
fatty acid
single cell
rna seq
bioinformatics analysis
long non coding rna
genome wide identification