A concise review on the role of MIR100HG in human disorders.
Seyedeh Morvarid NeishabouriAtefeh HarsijHossein FarahzadiBashdar Mahmud HussenMohammad TaheriMajid MokhtariPublished in: Journal of cellular and molecular medicine (2023)
MIR100HG is a long non-coding RNA (lncRNA) encoded by a locus on chr11:122,028,203-122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF-β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.
Keyphrases
- cell proliferation
- long non coding rna
- cell cycle
- poor prognosis
- endothelial cells
- pi k akt
- induced pluripotent stem cells
- long noncoding rna
- pluripotent stem cells
- fluorescent probe
- signaling pathway
- oxidative stress
- pulmonary fibrosis
- stem cells
- gene expression
- cell death
- endoplasmic reticulum stress
- transforming growth factor
- single molecule
- epithelial mesenchymal transition