Obesity is a public health concern resulting in a variety of health complications, including heart disease and insulin resistance. Estrogens have been associated with a reduced risk of obesity, but this relationship remains incompletely understood. We assessed the role of 17β-estradiol (E2) in mitigating complications associated with obesity by supplementing E2 in the diets of overfed zebrafish. We report that dietary E2 supplementation protects against weight gain and modulates de novo cholesterol synthesis in a sex-specific manner. Our studies lead us to propose a model in which E2 regulates hmgcr expression independently of unsaturated fat consumption. These data can be used to develop sex-specific treatments for obesity-related health conditions.
Keyphrases
- weight gain
- insulin resistance
- public health
- weight loss
- adipose tissue
- metabolic syndrome
- high fat diet induced
- type diabetes
- body mass index
- birth weight
- healthcare
- high fat diet
- skeletal muscle
- polycystic ovary syndrome
- mental health
- poor prognosis
- machine learning
- pulmonary hypertension
- health information
- fatty acid
- health promotion
- binding protein
- young adults
- human health
- gestational age