PHGDH and cancer: new job for an old enzyme!

Published in: The EMBO journal (2022)

How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non-canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer.

Keyphrases

papillary thyroid
oxidative stress
poor prognosis
squamous cell
social support
protein kinase
stress induced
depressive symptoms