PHGDH and cancer: new job for an old enzyme!
Duygu Kuzuoğlu-ÖztürkPublished in: The EMBO journal (2022)
How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non-canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer.