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PHGDH and cancer: new job for an old enzyme!

Duygu Kuzuoğlu-Öztürk
Published in: The EMBO journal (2022)
How do cancer cells bolster their energy metabolism under conditions of stress? Recent work by Shu et al (2022) unveils a novel, non-canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as a regulator of mitochondrial translation and tumor progression in liver cancer.
Keyphrases
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