Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis.

Yulia S KehayovaEmily WatsonJeremy Mark Wilkinson John Loughlin Sarah J Rice

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

COLGALT2 is a target of OA genetic risk at this locus. The genotype at rs11583641 impacts DNA methylation in a gene enhancer, which, in turn, modulates COLGALT2 expression. COLGALT2 encodes an enzyme that initiates posttranslational glycosylation of collagens and is therefore a compelling OA susceptibility target.

Keyphrases

genome wide
dna methylation
copy number
binding protein
knee osteoarthritis
gene expression
poor prognosis
transcription factor
rheumatoid arthritis
genome wide identification
genome wide analysis