Protective properties of extracellular vesicles in sepsis models: a systematic review and meta-analysis of preclinical studies.
Shujun YangKanglong ZhangJingyu HouXin LiuDaishi XuXuxiang ChenShuangmei LiYinghui HongChangqing ZhouHao WuGuanghui ZhengChaotao ZengHaidong WuJiaying FuTong WangPublished in: Journal of translational medicine (2023)
This meta-analysis showed that MSC-EVs treatment may be associated with lower mortality in animal models of sepsis. Subsequent preclinical studies will need to address the standardization of dose, source, and timing of EVs to provide comparable data. In addition, the effectiveness of EVs in treating sepsis must be studied in large animal studies to provide important clues for human clinical trials.
Keyphrases
- case control
- systematic review
- acute kidney injury
- septic shock
- intensive care unit
- clinical trial
- endothelial cells
- randomized controlled trial
- cell therapy
- risk factors
- big data
- stem cells
- mesenchymal stem cells
- deep learning
- bone marrow
- meta analyses
- replacement therapy
- machine learning
- induced pluripotent stem cells
- pluripotent stem cells