Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics.
Linda Marie O'KeeffeJoshua A BellKate N O'NeillMatthew A LeeMark WoodwardSanne A E PetersGeorge Davey SmithPatricia M KearneyPublished in: PLoS medicine (2022)
The results of this study suggest that associations of adiposity with adverse cardiometabolic risk begin earlier in the life course among males compared with females and are stronger until midlife, particularly for key atherogenic lipids. Adolescent and young adult males may therefore be high priority targets for obesity prevention efforts.