A Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model.

Natasha Haskey Jiayu Ye Mehrbod Estaki Andrea A Verdugo Meza Jacqueline A BarnettMitra YousefiBlake W Birnie Samantha Gruenheid Sanjoy Ghosh Deanna L Gibson

Published in: Gut microbes (2022)

A dietary blend of fats mimicking the MD, reduces disease activity, inflammation-related biomarkers and improves metabolic parameters in the Muc2 -/- mouse model. Our findings suggest that the MD fat blend could be incorporated into a maintenance diet for colitis.

Keyphrases

disease activity
systemic lupus erythematosus
rheumatoid arthritis
mouse model
rheumatoid arthritis patients
adipose tissue
ankylosing spondylitis
molecular dynamics
juvenile idiopathic arthritis
oxidative stress
ulcerative colitis
physical activity
weight loss
early onset
drug induced