Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma.

Sana Hosni Viola Kilian Niklas Klümper Daniela Gabbia Katharina Sieckmann Dillon Corvino Anja Winkler Miriam Saponaro Karin Woersdoerfer Doris Schmidt Oliver Hahn Ilaria Zanotto Marina Bertlich Marieta Ioana Toma Tobias Bald Markus Eckstein Michael Hudecek Matthias Geyer Manuel Ritter Dagmar Wachten Sara De Martin Abdullah Alajati

Published in: Cancer research (2024)

Acquired resistance to FGFR inhibition can be rapidly promoted by paracrine activation of the NRG1/HER3 axis mediated by adipocyte precursors and can be overcome by the combination of pertuzumab and erdafitinib treatment. See related commentary by Kolonin and Anastassiou, p. 648.

Keyphrases

adipose tissue
insulin resistance

fatty acid
epidermal growth factor receptor

metabolic syndrome

smoking cessation