Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition.
Liang FangLi ZhangMengran WangYuhao HeJiao YangZengjin HuangYing TanKe FangJun LiZhiyuan SunYanping LiYisen TangWeizheng LiangHuanhuan CuiQionghua ZhuZhe WuYiming LiYuhui HuWei ChenPublished in: Cancer research (2024)
Systematic investigation of the influence of posttranscriptional regulation on cancer cell motility established a connection between P-body-mediated translational control and EMT, which could be therapeutically exploited to attenuate metastasis formation.
Keyphrases
- epithelial mesenchymal transition
- genome wide
- transforming growth factor
- papillary thyroid
- signaling pathway
- crispr cas
- squamous cell
- genome editing
- dna methylation
- biofilm formation
- squamous cell carcinoma
- clinical trial
- randomized controlled trial
- childhood cancer
- gene expression
- staphylococcus aureus
- young adults
- pseudomonas aeruginosa
- cystic fibrosis
- study protocol
- candida albicans