SARS-CoV-2 Structural Proteins Exposure Alter Thrombotic and Inflammatory Responses in Human Endothelial Cells.
Christopher Thor FredaWei YinBerhane GhebrehiwetDavid A RubensteinPublished in: Cellular and molecular bioengineering (2021)
We observed significant increases in thrombotic and inflammatory marker expression, with no change to the cell culture parameters (with the exception of a reduction in cell density in response to one SARS-CoV-2 structural protein). Importantly, these observations were dependent on the viral structural protein the cells were exposed to, suggesting that the interactions of SARS-CoV-2 with innate cells is complex and must be uncovered. Combined, this suggests that SARS-CoV-2 structural proteins can regulate inflammatory and thrombotic responses that underlie common pathologies observed during COVID-19.
Keyphrases
- sars cov
- endothelial cells
- induced apoptosis
- respiratory syndrome coronavirus
- cell cycle arrest
- oxidative stress
- immune response
- poor prognosis
- binding protein
- single cell
- endoplasmic reticulum stress
- amino acid
- stem cells
- signaling pathway
- cell therapy
- high glucose
- bone marrow
- small molecule
- pi k akt
- pluripotent stem cells