Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis.

Yan ZhangYuan ZhouIngrid A F van der MeiSteve Simpson YapAnne-Louise PonsonbyRobyn M LucasPrudence TetteyJac CharlesworthKaram KostnerBruce V Taylornull null

Published in: Journal of neurology, neurosurgery, and psychiatry (2019)

In this prospective cohort study, both lipid levels and lipid-related polymorphisms individually and jointly were associated with significantly increased disability progression in MS. These results indicate that these polymorphisms and tagged genes might be potential points of intervention to moderate disability progression.

Keyphrases

multiple sclerosis
fatty acid
white matter
randomized controlled trial
genome wide
gene expression
climate change
human health