Gene expression and autoantibody analysis reveals distinct ancestry-specific profiles associated with response to rituximab in refractory systemic lupus erythematosus.
Lucy Marie CarterAdewonuola AlaseZoe WigstonAntony PsarrasAgata BurskaEmily SuttonMd Yuzaiful Md YusofJohn A Reynoldsnull nullNeil McHughPaul EmeryMiriam WittmannIan N BruceEdward M VitalPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Ancestry appears central to the immunological and clinical heterogeneity in SLE. These results suggest that ancestry, disease activity and transcriptional signatures could each assist predict the effectiveness of B-cell depletion. This article is protected by copyright. All rights reserved.
Keyphrases
- disease activity
- systemic lupus erythematosus
- gene expression
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- genome wide association study
- juvenile idiopathic arthritis
- randomized controlled trial
- dna methylation
- systematic review
- diffuse large b cell lymphoma
- genome wide
- transcription factor
- oxidative stress
- chronic lymphocytic leukemia