Systematic Review on Individualized Versus Standardized Parenteral Nutrition in Preterm Infants.
Walter Alexander MihatschMiguel Ángel Jiménez VarasLucia Lorenzino DiehlVirgilio CarnielliRahel SchulerCorinna GebauerMiguel Saenz de PipaonPublished in: Nutrients (2023)
The need for high quality evidence is recognized for optimizing practices of parenteral nutrition (PN). The purpose of the present systematic review is to update the available evidence and investigate the effect of standardized PN (SPN) vs. individualized PN (IPN) on protein intake, immediate morbidities, growth, and long-term outcome in preterm infants. A literature search was performed on articles published in the period from 1/2015 to 11/2022 in PubMed and Cochrane database for trials on parenteral nutrition in preterm infants. Three new studies were identified. All new identified trials were nonrandomized observational trials using historical controls. SPN may increase weight and occipital frontal circumference gain and lower the value of maximum weight loss. More recent trials suggest that SPN may easily increase early protein intake. SPN may reduce the sepsis incidence, but overall, no significant effect was found. There was no significant effect of standardization of PN on mortality or stage ≥2 necrotizing enterocolite (NEC) incidence. In conclusion SPN may improve growth through higher nutrient (especially protein) intake and has no effect on sepsis, NEC, mortality, or days of PN.
Keyphrases
- preterm infants
- systematic review
- low birth weight
- weight loss
- meta analyses
- risk factors
- body mass index
- protein protein
- intensive care unit
- acute kidney injury
- cardiovascular events
- primary care
- healthcare
- emergency department
- bariatric surgery
- binding protein
- type diabetes
- physical activity
- randomized controlled trial
- cross sectional
- adipose tissue
- roux en y gastric bypass
- skeletal muscle
- body weight
- insulin resistance
- gastric bypass
- cardiovascular disease
- preterm birth
- case control