Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.

Jiannong LiInna SmalleyZhihua ChenJheng-Yu WuManali S PhadkeJamie K TeerThanh NguyenFlorian A Karreth John M KoomenAmod A SarnaikJonathan S ZagerNikhil I KhushalaniAhmad A Tarhini Vernon K Sondak Paulo C Rodriguez Jane L Messina Yian Ann Chen Keiran S M Smalley

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Acral melanoma has a suppressed immune environment compared with that of cutaneous melanoma from nonacral skin. Expression of multiple, therapeutically tractable immune checkpoints were observed, offering new options for clinical translation.

Keyphrases

single cell
skin cancer
poor prognosis
rna seq
genome wide
basal cell carcinoma
high throughput
gene expression
dna methylation