Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.
Mayuki TachizakiYuri KoboriShogo KawaguchiKazuhiko SeyaHiroshi TanakaTadaatsu ImaizumiPublished in: Molecular biology reports (2024)
CYLD may prevent excessive inflammation due to an antiviral innate immune response by suppressing IKK complex and NF-κB activation downstream of TLR3 in hRPTECs.
Keyphrases
- immune response
- toll like receptor
- oxidative stress
- endothelial cells
- nuclear factor
- poor prognosis
- dendritic cells
- signaling pathway
- inflammatory response
- lps induced
- induced pluripotent stem cells
- high glucose
- pluripotent stem cells
- liver injury
- weight gain
- binding protein
- liver fibrosis
- physical activity
- body mass index
- drug induced